Trabecular meshwork pigmentation is a manifestation of the clinical diagnosis of pigmentary glaucoma. Pigmentary glaucoma is a secondary open-angle glaucoma caused by pigmentation of the anterior segment of the eye. It is often easily confused with iris pigment loss and uveitis symptoms and is usually treated with medication first, followed by laser treatment, and finally surgery is considered. Important risk factors affecting the development and progression of PDS are: young people, men, myopia and Caucasians. the danger of PG for society is that it develops at the age when people start their career peak, thus causing a great impact on society and families. In Western societies, PG accounts for 1 to 1.5% of all glaucoma PDS generally occurs in young people, with an age of onset of 20 to 45 years, but it also occurs in older people PDS has the same proportion of men and women. However, PG is more common in men, with a male to female ratio of about 3:1. The age of onset of PD in women is about 10 years later than in men, with an average age of 46 to 53 years, and 34 to 46 years in men. For PDS, myopia is a risk factor. It has been found that the higher the degree of myopia, the younger the age at which glaucomatous optic disc damage occurs. Patients with PDS who have significant asymmetry in their anterior chamber depth have been found to have asymmetric iridocorneal angle depth. Caucasians are more likely to develop the disease, and it is rare in people of color and rare in Orientals. Cases of PG have been reported in mulatto families and in blacks with albinism. Most cases of PDS/PG are disseminated and there is rarely a family history. Shortly after abnormal pigmentation in the anterior chamber was reported, families with Krukenberg’s shuttle were also reported. It was not until the 1980s that it was reported that PDS could be a familial disease PDS is autosomal dominant and the gene associated with this syndrome is located at the end of the long arm of chromosome 7 (7q35-q36). The localization of the gene associated with this disease is the first step in the isolation of this gene, and the characterization of the gene will help to elucidate the pathophysiological and biochemical features of PDS. In addition, other specific conditions, such as large eyes and large corneas, can also be associated with the development of PDS/PG. However, no risk for PDS has been found in congenital glaucoma with progressively larger eyes.