There is no quick pain relief for diabetic patients with toothache, diabetic patients with toothache usually need to use pain medication to relieve the pain on the basis of active control of blood glucose, and then according to the cause of the toothache to carry out the appropriate treatment, such as root canal treatment, periodontal therapy, and so on. Diabetic patients with toothache, the first thing is still to actively control blood sugar, can use insulin or oral hypoglycemic drugs, such as sulfonylureas, glargine, biguanides, etc. for treatment, if the toothache is serious, you can use ibuprofen and other non-steroidal anti-inflammatory drugs to relieve the pain. While controlling blood sugar, you can go to the dentist to check the diseases that cause toothache and treat them accordingly. For example, periodontitis can be cleaned according to blood sugar control; pulpitis and apical periodontitis need root canal treatment. Diabetic patients with toothache should consult the doctor in time and choose the treatment method under the doctor’s guidance. The use of drugs need to follow the doctor’s instructions.