Patient: Description (onset time, main symptoms, hospital, etc.): I suffer from iritis often, the doctor suspected that I have ankylosing spondylitis, let me do several tests, the last one is the pelvic MRI, the results came out of the pelvis are good, found that there is Douglas trap effusion, what is this disease ah? How do you get it? Is it serious? What kind of treatment is needed? Yang Xiaobing, Department of Rheumatology and Immunology, Huzhou Third People’s Hospital: Ankylosing spondylitis mainly affects the mid-axis joints, with sacroiliac arthritis being the most common and characteristic, and a positive HLA-B27 can aid in the diagnosis. If you have recurrent episodes of iritis, if you also have lower back pain and the pain is characterized by relief after activity and aggravation after rest, you should pay more attention to the possibility of ankylosing spondylitis. If the test is positive, you may have ankylosing spondylitis. The current view is to diagnose and treat early to prevent joint destruction. Treatment is now preferred to biologics (economic conditions permitting), or immunosuppressive agents such as thalidomide and pain medications.