There are various reasons for patients to have vague pain in the middle of the upper abdomen, first of all, we need to consider that it may be caused by cold in the abdomen. If the patient fails to add clothes in time when the weather turns cold, causing the abdomen to get cold, there may be vague pain in the middle of the upper abdomen and abdominal distension and other manifestations. In addition, it is not excluded that it is caused by abdominal diseases, thoracic diseases, systemic diseases, etc.: a. Abdominal diseases: 1. Inflammatory lesions: including gastroenteritis, gastric ulcer, corrosive gastritis, reflux esophagitis, etc., the most common of which is gastroenteritis, mainly due to acute inflammation of the gastrointestinal mucosa caused by viral and bacterial infection, patients often have diarrhea, vomiting and other discomfort symptoms in the middle of the upper abdomen. In addition, the gallbladder is located above the right abdomen, when local inflammation, pain can be radiated to the upper abdomen central; 2, organ torsion: acute gastric torsion, gallbladder torsion and other diseases, can cause patients with severe pain in the upper abdomen, nausea, abdominal distension and other uncomfortable symptoms, and usually the pain will also involve the back, patients need to promptly seek medical advice to avoid complications necrosis, perforation, ulcers and other serious situations; 3, vascular lesions: such as acute portal vein thrombosis, abdominal aortic aneurysm, etc., patients are often accompanied by epigastric and low back nerve root pain, and the nature of the pain is distension or knife-like pain. Second, thoracic diseases: myocardial infarction, acute pericarditis, angina pectoris, heart failure and other thoracic diseases, due to abnormal heart function, resulting in the amount of cardiac blood displacement can not meet the metabolic needs of the body tissues, patients often have chest pressure pain, and the pain can be radiated to the jaw, neck, upper back, upper abdomen. Third, systemic diseases: If the patients themselves have systemic diseases, such as abdominal allergic purpura, abdominal epilepsy, diabetic ketoacidosis, etc., they will have nausea, vomiting, and periodic recurrent episodes of vague pain in the middle of the upper abdomen.