If the nipple of the female breast does not protrude from the areola plane, or even concave, sinking below the surface of the breast, resulting in a crater-like localization, it is called nipple invagination. The causes are divided into: congenital and acquired nipple invagination. Congenital nipple invagination is mostly caused by development. Acquired nipple invagination is most commonly seen in chronic ductitis of the breast, breast cancer, chronic inflammation of the breast, and also in macromastia, after breast surgery, etc. Nipple invagination is a more common deformity, more common bilaterally and more often secondary unilaterally. There are no exact statistics on the incidence of congenital nipple invagination. It is about 1-2%. Among its occurrence factors, genetic factors play an important role in congenital nipple invagination. In acquired nipple invagination, the infection factor is one of the main factors of nipple invagination, mainly mammary ductitis with fibrotic scar contracture affecting its normal development can cause nipple invagination. The significance of nipple invagination in malignant tumors of the breast is different. In women with normal breasts, if there is no obvious reason for nipple invagination, mammography should be performed to help diagnose such cases of nipple invagination. In congenital nipple invagination, attention should be paid to breast care and regular nipple exercises should be performed. If this is not possible, nipple inversion correction should be performed before pregnancy. Acquired nipple invagination should be treated by actively visiting the hospital for the primary cause.