Commonly used drugs for Mycoplasma hominis infection are macrolide antibiotics, commonly used erythromycin, erythromycin, azithromycin and so on. Mycoplasma hominis often causes urinary and genital infections, and is mainly sexually transmitted in adults and mother-to-child in infants, with newborns often presenting with pneumonia or conjunctivitis. Mycoplasma hominis infections need to be treated with macrolide antibiotics, such as erythromycin, roxithromycin, azithromycin, and so on. Use with caution in patients with macrolide antibiotic allergy and severe hepatic or renal insufficiency. The most common adverse reactions are gastrointestinal reactions, manifested as nausea, abdominal pain, diarrhea, etc. In addition, macrolide antibiotics have a certain degree of ototoxicity and cardiotoxicity, which should be taken seriously. People with Mycoplasma hominis infection need to consult a doctor in time and apply drugs under the guidance of the doctor to avoid the spread of infection.