There are negative and positive HER2 breast cancers. Breast cancer cells with higher than normal levels of HER2 (human epidermal growth factor receptor-2) are called HER2-positive. These cancers are more likely to grow and spread than other breast cancers. There is a large difference between negative and positive breast cancers in terms of cure rates as well as prognosis. Typically, HER2-positive has a poor prognostic ability. HER2 (human epidermal growth factor receptor-2) negative usually means that the cancer can be controlled and the patient’s life expectancy can be increased and prolonged. Negative is good compared to positive and has a higher success rate of cure. If the result is 0 or 1+, the cancer is considered HER2 negative. If the result is 3+, the cancer is HER2-positive. People with HER2-positive invasive breast cancer are advised to undergo chemotherapy as well as targeted therapy. Surgery is recommended when the patient is in the negative or positive stage of breast cancer to remove the root cause of the cancer as early as possible and in a timely manner. After breast cancer surgery, patients must undergo regular review to prevent deterioration, recurrence and metastasis of the disease. In daily life, patients must actively exercise to improve their immunity. And to maintain an optimistic and positive attitude, the emotional state of cancer patients is crucial to the treatment of the disease.