When a patient has symptoms of headache, chest tightness, shortness of breath and nausea, the first thing to consider is the possibility of respiratory infections, such as pneumonia, which requires blood tests and chest X-rays for a clear diagnosis. It is also important to consider that the patient’s headache is related to the patient’s dyspnea. When the patient has difficulty in breathing, this is when the body becomes hypoxic. The brain is extremely sensitive to the lack of oxygen and the patient will have headache symptoms. This is the time to consider whether the patient has an acute myocardial infarction. Many patients present with a painless infarction, which is not clinically evident. Patients can have an electrocardiogram and myocardial enzymology to make a definitive diagnosis. In addition, it is important to consider whether an acute pulmonary embolism has occurred. The patient’s symptoms are caused by the presence of a pulmonary embolism. Or the patient may have a pneumothorax, and the patient is advised to have a pulmonary examination.