Diabetes mellitus caused during taking Methylprednisolone can generally return to normal level after stopping the drug, which has a close correlation with its own body metabolic status. During the application of Methylprednisolone, it may lead to the increase of gluconeogenesis, causing the rise of blood glucose in the body, but the patient’s own pancreatic islet function is not abnormal, so after the gradual discontinuation of the drug, the blood glucose will generally fall to the normal level. Methylprednisolone should not be stopped suddenly, and must be used reasonably under the guidance of the clinician to prevent the recurrence of symptoms caused by irregularity in stopping the medication; in addition, the application of methylprednisolone may produce certain side effects, and after the cessation of the medication, we should pay attention to dietary modification, strengthen the exercise, and promote the recovery of the body. If there is any discomfort, you should go to the hospital in time and get treatment under the doctor’s guidance, so as to avoid delaying the condition.