Thyroid disease, the second most common endocrine metabolic disease, has received much less attention than diabetes. Even though methimazole (a drug with the indication of hyperthyroidism) was once sold out of stock, thyroid disorders have not received enough attention. Among thyroid disorders, Hashimoto’s thyroiditis is gaining ground: the incidence of this disease is increasing every year, the course of the disease is long, and it can have lifelong effects. Today, it only takes 3 minutes to understand this disease in detail. The following contents are the valuable experience of endocrinologists and are explained in depth. 1. why the name is strange As this disease was discovered due to the first case report presented by a Japanese physician, and later named after him, Hashimoto’s. 2. 2, in which people common female high prevalence, the onset of age for young and middle-aged, in recent years the onset of the trend of lower age. 3.What are the clinical manifestations? At first there is no special feeling, the thyroid gland is symmetrical but gradually increases in size. There are multiple stages of hyperthyroidism, hyperthyroidism with hypothyroidism, hypothyroidism and other different manifestations, and elevated autoantibodies to the thyroid gland can be seen in blood tests. The disease is now mostly considered to be a chronic inflammatory reaction and an autoimmune disease. 4.In-depth explanation These changes in performance are due to the destruction of the cells of the thyroid gland by antibodies. On the one hand, the large amount of T3 and T4 stored in the cells that have not been released into the bloodstream enters the bloodstream after cell destruction, which may produce the clinical manifestations of hyperthyroidism; on the other hand, as more and more cells are destroyed, the amount of T3 and T4 eventually tends to be depleted, i.e. hypothyroidism. Therefore, it is typical to go through such a course: (1) Transient hyperthyroidism The general course is a few months, most of them have no clinical symptoms, even no increase in FT4. This is related to the speed of thyroid destruction, the speed of destruction is fast, more is released in a short period of time, it is easy to be hyperthyroid, high values of antibody test may be suggestive. (2) Stable phase After the transient hyperthyroidism, there will be a stable phase. After all, the thyroid gland is also the kind of organ with abundant reserves, and it is not that easy to be hypothyroid. (3) Hypothyroidism Eventually, the disease will go into hypothyroidism. TOPAb is an anti-thyroid peroxidase antibody, which is the preferred indicator for the diagnosis and differential diagnosis of Hashimoto’s hyperthyroidism. If we understand that hyperthyroidism is at most transient in nature, then drugs such as ATD, surgery and I131 are redundant, and ATD itself has no effect on the T3 and T4 that have been released into the blood. The effect is what? beta-blockers. This is the amount of GD, Hashimoto can be smaller than this amount. Patients with good thyroid function can be treated without intervention, and methods for the autoimmune process have not yet been studied. Entering hypothyroidism, replacement therapy.