131I is an important tool in the postoperative treatment of DTC. 131I treatment consists of two levels: first, 131I is used to remove residual thyroid tissue after DTC surgery (131Iablationforthyroidremnant); second, 131I is used to remove metastases of DTC that cannot be removed by surgery (131I clearance). The significance of 131I nail clearing after DTC surgery includes: ①It facilitates the monitoring of disease progression through serum Tg and 131I whole body imaging (wholebodyscan,WBS). ②It is the basis of 131I focal clearance treatment. ③WBS and single photon emission computed tomography (SPECT)/CT fusion imaging after nail clearing are useful for re-staging DTC. (iv) Possible treatment of underlying DTC lesions. The indications for postoperative 131I nail clearing therapy are still controversial, with the main question focusing on whether low-risk patients benefit from it. Combining ATA recommendations, the actual situation in China and clinical experience, it is recommended that patients with postoperative DTC should be evaluated in real time and 131I nail clearing therapy should be selectively implemented according to TNM staging. Overall, 131I nail-clearing therapy can be considered except for all DTC with cancer foci <1 cm and no extra-glandular infiltration, lymph nodes and distant metastases. 131I nail scavenging is contraindicated during pregnancy, lactation, planned short-term (6-month) pregnancy, and those who cannot follow radiation protection instructions.