The typical symptoms of acute cholangitis are Charcot’s triad of abdominal pain, fever and jaundice. The abdominal pain is usually in the upper right or upper middle abdomen and can be intense and colicky. In severe cases, patients may experience central nervous system depression such as restlessness, impaired consciousness, lethargy or even coma, often accompanied by shock such as a drop in blood pressure, which can even be life-threatening. Patients with chronic cholangitis may have recurrent symptoms of acute cholangitis, and are prone to fatigue, anorexia, weight loss, abdominal pain, fever, jaundice and itching of the skin.