The prognosis of primary biliary cholangitis is determined by the extent to which it is diagnosed early. The prognosis of patients with primary biliary cholangitis stage, if diagnosed, is good and the survival time is similar to that of normal people. If not diagnosed and treated in a timely manner, primary biliary cholangitis progresses by one stage every 1.5 years on average, from cholangitis to cirrhosis, which is an average of 6 years. Liver function, mainly looking at alkaline phosphatase and gamma-GT, and the signature antibody is anti-mitochondrial antibody. If there is cholestasis, abnormal liver function and positive anti-mitochondrial antibodies, these patients should be treated early to prevent the development of cirrhosis. Once cirrhosis develops, the prognosis is very, very poor, similar to the prognosis for hepatitis B cirrhosis and hepatitis C cirrhosis.