Chest tightness and shortness of breath can not be found, the possible clinical causes are serious coronary heart disease, heart failure, lung disease. 1. severe coronary heart disease: this condition is often associated with coronary artery atherosclerosis, which can cause serious blockage of the coronary arteries and cause myocardial ischemia, resulting in frequent tightness in the chest and shortness of breath, as well as wheezing. 2. Heart failure: clinically, it will cause chest tightness, wheezing and other symptoms are mostly seen in the left heart heart failure, people suffering from the disease of the left ventricle of the pumping ability almost disappeared and make the blood in the pulmonary veins to produce stagnation, the clinical manifestations of chest tightness, shortness of breath, wheezing, coughing up red foamy sputum, and so on. 3. Lung diseases: clinically common such diseases are chronic bronchitis, lung infections, chronic obstructive pulmonary disease, lung cancer, etc., which will make the people with such diseases have weakened lung function, clinical manifestations of wheezing, dyspnea, chest tightness, and so on. It is recommended that people with this condition should go to the hospital as soon as possible for examination to make a clear diagnosis, and carry out targeted treatment according to the doctor’s instructions.