Diabetic numbness pinprick sensation in hands and feet may be caused by diabetic peripheral neuropathy, which is one of the common complications of diabetes mellitus, and can be treated with hypoglycemic therapy, improvement of metabolism, nutritional nerves and symptomatic treatment. 1. Hypoglycemic therapy: choose the appropriate hypoglycemic program (oral hypoglycemic drugs or insulin subcutaneous injection), and actively control blood glucose within the standard range. 2. Improvement of metabolism: use of anti-oxidative stress drugs (α-lipoic acid), improve metabolic disorders drugs (aldose reductase inhibitors), help to improve microcirculation and metabolism, slow down the progress of diabetic peripheral neuropathy. 3. Nerve nutrition and repair: various B vitamin drugs (methylcobalamin, vitamin B1, etc.) can be used, which can nourish the nerves and promote nerve repair. 4. Symptomatic treatment: the use of gabapentin, pregabalin and other pain medications can improve the symptoms of nerve pain in patients. Diabetic numbness of the hands and feet pinprick sensation may also be caused by diabetic vasculopathy and other causes, diabetic numbness of the hands and feet pinprick sensation, it is recommended to consult a doctor in a timely manner, under the guidance of a professional doctor for treatment.