There is not much difference in the effectiveness of the removal of warts between the coltsfoot toxin cream and the imiquimod cream. The onychotoxin is an anti-tumor ingredient extracted from plants, which works by corroding the warts to achieve the effect of surface wart removal. Onychocerca volvulus cream is mainly applied to the treatment of warts on the external genitals and perianal areas of men and women. Adverse reactions include burning and pain after application, as well as superficial erosion after wart removal. Imiquimod cream is a synthetic non-nucleoside isocyclic amine drug, can stimulate the body to produce a variety of cytokines, enhance the cellular immune response, in order to facilitate the removal of the human papilloma virus (i.e., the pathogen that causes warts), the adverse effects of redness, swelling and hot pain, and vesiculation, ulceration, and so on, after applying. If warts appear, it is recommended to go to the hospital in time for early and regular treatment. Both of these drugs should be used under medical supervision.