Brittle bone disease, a form of osteogenesis imperfecta, which manifests as bone fragility, blue sclera, deafness, and joint laxity, is a congenital genetic pain due to hypoplasia of mesenchymal tissue and impaired collagen formation. The incidence is equal in males and females. It can be divided into two types: congenital type and late type. The congenital type refers to the onset of the disease in utero and can be subdivided into fetal and infantile types. The disease is severe and most of them die, or die within a short period of time after delivery. It is autosomal recessive, while the late-onset form is milder and can be divided into pediatric and adult forms. The majority of patients survive for a long time and are autosomal dominant. 15% or more of patients have a family history. The fracture should be reset and fixed as usual. Nutritional care should be taken to avoid injury. Bisphosphonates have been described in the literature as a treatment for this disease. Overview Brittle bone disease, a form of osteogenesis imperfecta, manifested by bone fragility, blue sclera, deafness, and joint laxity, is a congenital hereditary pain due to hypoplasia of mesenchymal tissue and impaired collagen formation. The incidence is equal in males and females. It can be divided into congenital type and late type. Congenital type refers to the onset of the disease in utero and can be subdivided into fetal type and infantile type. The disease is severe and most of them die or die within a short period of time after delivery. It is autosomal recessive, while the late-onset form is milder and can be divided into pediatric and adult forms. The majority of patients survive for a long time and are autosomal dominant. 15% or more of patients have a family history of the disease. There is no specific treatment for this disease. The fracture should be reset and fixed as usual. The patient should pay attention to nutrition and avoid injury. Clinical picture 1. Fractures: Fractures can be caused by minor injuries or daily activities. The fracture can join on its own, but slowly. It may not occur again after the young age. 2. Blue eyes: Patients may have dark blue sclera, caused by the pigmented outgrowth of the ocular choroid. 3. Deafness: It is mostly seen in patients over 20 years of age and is caused by sclerosis of the small bones in the ear. About 25% of cases suffer from deafness. 4. Other: muscle weakness, joint laxity, short stature, incomplete calcification of mammary teeth as translucent, but normal intelligence.