Knee pain while running indicates that the cartilage between the patella and the femur has been damaged, at which point the patient needs to rest and cannot continue running. It is important to pay attention to knee pain after running and find the cause, which may be osteoarthritis of the knee or inflammatory disease of the synovial membrane of the knee. Patients should pay attention to rest, can be localized hot compresses, external use of blood pain relief cream, or oral non-steroidal pain medication, such as ibuprofen extended-release capsules. It is not possible to continue running at this time, otherwise the local inflammatory disease may become more serious, leading to soft tissue damage, damage to joint cartilage and the occurrence of osteoarthritis. If the knee joint is painful for a long time, you need to go to the hospital joint surgery or sports medicine department for a detailed examination to clarify whether there is meniscus damage. Before running, you should pay attention to fully warming up, stretching muscles, choosing a suitable sports ground, avoiding hard or uneven ground, and not too much exercise at the beginning, but gradually increasing the amount of exercise.