Prior to the introduction of effective antiviral therapy, cirrhosis was generally considered irreversible by the medical community. However, in recent years, various studies on antiviral therapy for chronic viral hepatitis, including the “lamivudine 4006 study”, have found that early cirrhosis in some patients with chronic viral hepatitis can be reversed to a large extent or even disappear after effective antiviral therapy, and this phenomenon has been confirmed in a significant number of patients after effective antiviral therapy in our clinic. This phenomenon has also been confirmed in a significant number of patients after effective antiviral treatment. Why does this change occur? First of all, it is due to the removal or control of the cause of the disease. Previously, our clinical lack of understanding and effective control means for the various causes of cirrhosis led to the persistence of causative factors, and liver damage continued to progress slowly even with extreme liver preservation and anti-fibrosis treatment measures, and could not reach complete cessation, leading to the conclusion that cirrhosis is irreversible; that is, our previous treatment was symptomatic but not curative, and could not Therefore, for some patients with cirrhosis whose etiology we cannot control yet, such as cirrhosis caused by chronic schistosomiasis infection and autoimmune hepatitis, we cannot reverse their existing cirrhotic changes. Secondly, this is also based on the fact that hepatocyte tissue can be regenerated and repaired. Liver cell tissue has a strong regenerative and repair ability, and after we remove the causative factors and supplement with suitable conditions and sufficient nutrition, liver cell tissue can be well regenerated and repaired, which can be well reflected in the rapid growth of liver in partial hepatectomy and transplantation patients. Of course, the liver regeneration and repair ability is strong, but after all, it is limited. For patients who have developed severe cirrhosis or even decompensation, it is almost impossible to completely reverse it, so, at present, we can only say that cirrhosis can be partially reversed. Therefore, etiological treatment is the key, we must first clarify the cause of cirrhosis, and try to control and eliminate its causative factors, for example, chronic viral hepatitis must be treated with antiviral therapy; of course, related adjuvant therapy and adequate nutritional supply are also very important for the reversal of cirrhosis, and we should also pay great attention to it. Of course, although it is confirmed that cirrhosis can be reversed, but only for liver diseases whose causes we can control, and only to varying degrees of partial reversal, patients with liver disease should not be taken lightly, we should still treat as early as possible to control the progress of the disease, to prevent the development of severe cirrhosis to bring adverse effects on the quality of life and long-term prognosis.