Atherosclerotic occlusive disease is a common disease in the elderly, with a prevalence of nearly 20%. The symptoms of atherosclerosis-occlusive disease are not obvious in the early stages, thus it is not conducive to early detection and early diagnosis of atherosclerosis-occlusive disease. However, in the initial stage, most patients will have intermittent claudication. Therefore, intermittent claudication can be an important marker for determining atherosclerotic occlusive disease. Intermittent claudication is an early clinical manifestation of insufficient blood supply to the arteries of the lower extremities. If patients with atherosclerosis-occlusive disease do not pay enough attention at this stage, it can lead from “intermittent claudication” to “resting pain”, and in severe cases of atherosclerosis-occlusive disease, gangrene of the lower limbs can occur. The term “rest pain” refers to the gradual and severe pain that occurs in patients with atherosclerosis-occlusive disease even when they are not walking, especially at night. Gangrene” refers to signs of necrosis such as darkening of the skin and impairment of movement in the terminal areas of the main limbs of patients with atherosclerosis-occlusive disease. Intermittent claudication has two regression results: first, after certain treatment to eliminate the curative factors of atherosclerosis-occlusive disease, the walking distance is extended and the atherosclerosis-occlusive disease is controlled. Second, the atherosclerotic occlusive disease is not treated in a timely and correct manner or the treatment is not effective, resulting in the continued progression of the disease process and the possible end result of amputation. Lower extremity atherosclerosis occlusive disease is a more serious peripheral vascular disease, and the prevalence is high, so patients must pay sufficient attention. Early detection and treatment of atherosclerotic occlusive disease is necessary, and both patients and physicians should pay attention to the early manifestation of intermittent claudication to prevent missed diagnosis and misdiagnosis.