Lower extremity deep vein thrombosis is the most common clinical peripheral vascular disease in which the blood in the deep vein system clots and forms thrombus due to various reasons. When thrombosis is formed, blood from the lower limbs cannot return to the heart smoothly, and a large amount of blood is retained in the lower limbs, which increases the venous pressure and causes extravasation of blood components, resulting in clinical manifestations such as limb swelling and pain. Zhou Tao of Peripheral Vascular Department of the First Affiliated Hospital of Henan College of Traditional Chinese Medicine Thrombolytic therapy is the main treatment for acute lower limb deep vein thrombosis, and the traditional route of drug delivery is mainly through peripheral peripheral veins. If the drug is administered through peripheral venous system, most of the drugs are returned through superficial veins or collateral circulation, and the local blood concentration at the thrombus site is low, and to increase the local blood concentration, a large drug dose is required, and the large dose of thrombolytic drugs is very likely to cause bleeding in various tissues and organs of the body, and the safety of treatment is difficult to guarantee. Catheter thrombolysis has become one of the important means of treating acute deep vein thrombosis clinically, especially the use of direct thrombolysis with intracavitary catheters has greatly improved the restoration of deep vein trunk patency and the preservation of deep vein valves. Endoluminal catheter contact thrombolysis is to insert the thrombolytic catheter directly into the thrombus and continuously push the thrombolytic drug by micro-pump, thus greatly shortening the time for the drug to reach the lesion and increasing the local blood concentration, which can give full play to the efficacy of the thrombolytic drug and achieve the purpose of eliminating the thrombus. Before treatment, the imaging showed extensive thrombosis of the left iliofemoral vein (in prone position), and after treatment, the imaging showed that the lesion was basically open.