Fever is the most common symptom in life, and there are various manifestations throughout the fever: cold hands and feet, chills, sweating, etc. Here we introduce the measures we can take to help us be more comfortable when our hands and feet are cold, and to help relieve the symptoms. First of all, the whole process of fever is roughly divided into three stages: the first stage of various thermogenic sources to raise the hypothalamic body temperature regulation point. In the second stage, the blood vessels, fat, muscles and other tissues and organs work together instinctively to help reach this thermoregulation point. In the third stage, the body is returned to its normal thermoregulation point by various means. Cold hands and feet during fever occur in the second stage, when the blood vessels activate the motor neurons and heat-sensitive neurons of the blood vessels in order to cooperate with the hypothalamus to reach a higher thermoregulation point, causing the blood vessels to constrict, slowing down the firing frequency of their heat-sensitive neurons and increasing peripheral heat production. The vasoconstriction and the flow of blood from the periphery to the internal organs will make the hands and feet feel cold significantly, and you will have cold hands and feet. What we need to do at this point is to expose less body surface area to help raise body temperature, we need to wear more clothes or cover with a quilt to cover the heat, to help the hypothalamus quickly reach the elevated body temperature adjustment point. It is good to enter the third stage where everyone is working together to return to normal body temperature. After the analysis of the whole process of fever, we know that when the fever is cold hands and feet we should reduce the exposure of the body to cover the heat to reduce heat dissipation to help reach the body temperature adjustment point, when sweating we should dissipate heat to help restore body temperature, which will make us feel more comfortable and make the whole process a little faster. I hope my sharing will be helpful to you.