Broad indications are as follows: (a) Clearing aspect Almost all open wounds, including: abscesses, burns, cellulitis, ulcers, gangrene, osteomyelitis, co-infected surgical wounds, post-surgical incision infections, tumor ulcers, etc., especially for diabetic foot ulcers and decubitus ulcers. Maggot treatment is also feasible for non-open infections that have become open wounds through surgery. Some wounds that were originally contraindicated by maggot therapy can also be converted into indications by changing the way maggots are used. (ii) Anti-infective aspects: There is increasing evidence that maggots can treat complex wounds caused mainly by methicillin-resistant staphylococcal (MRSA) infections and hospital-acquired infections such as Pseudomonas aeruginosa infected wounds. Some of the literature has explicitly included MRSA infections as an indication for maggot therapy. Other bacteria such as Streptococcus, Klebsiella, Streptococcus pepticus, coagulase-negative staphylococci, and Staphylococcus aureus can also be treated with maggot therapy with good results. Some bacteria form biofilm on the traumatic surface, which is an important reason for high drug resistance of bacteria, and maggots can remove bacterial biofilm by mechanical and chemical action, so that bacteria have no place to hide. (iii) Promote the growth of granulation tissue Some wounds can be treated by changing medicine and applying various drugs locally, the condition of ulcer can be improved, the secretion is reduced and the granulation becomes fresh, but the ulcer is still difficult to heal, which is called refractory wounds. In contrast, maggots can stimulate the growth of granulation tissue on the trauma surface through various mechanisms such as mechanical stimulation and secretion of bioactive substances.