Maggot therapy, also known as biological debridement, is a treatment that artificially and purposefully places live sterile maggots into unhealed skin or soft tissue wounds of humans or animals to remove necrotic tissue and pathogenic bacteria for the purpose of wound healing. The maggots used are usually the larvae of the Silky Fly. Fly maggot disease is a disease in which maggots invade the organs or tissues of humans or other vertebrates and feed on live or necrotic tissues for at least a period of time, or invade the intestine to feed on food ingested by the host. Fly maggot disease can be classified by site into eye, ear, nose and mouth fly maggot disease, skin fly maggot disease, digestive tract fly maggot disease and genitourinary tract fly maggot disease. Eye fly maggot disease is often caused by sheep fly larvae, while skin fly maggot disease is often caused by bull fly larvae. The silky flies can lay eggs in human wounds and sores or parasitize in the digestive tract and the five senses, causing digestive tract maggot disease and nasal fly maggot disease in humans, and also in domestic animals and poultry. However, when purulent otitis media or cerebrospinal fluid leakage occurs in the external ear canal, the secretions from the external ear canal attract flies to lay eggs. There have been no reports of ocular or urinary tract fly maggot disease caused by C. filiformis. Maggot therapy is a controlled, therapeutic form of fly maggot disease, its safety and efficacy are monitored, and most potential complications are predictable and preventable. In contrast, fly maggot disease, in which wild flies lay eggs or maggots on live human skin or natural cavities or wounds, is called natural or non-therapeutic fly maggot disease.