With the continuous improvement of fat suction and grafting technology, the incidence of serious complications has been gradually reduced, the clinical effect has become more and more perfect, the indications have been expanded, and the number of people undergoing the surgery has been increasing day by day. According to the age of consultation and surgery to analyze, from 10-year-old children’s deformity correction, to eighty or ninety years of age to do facial fat depression filler, can be safe for surgery, age is no longer an absolute contraindication to liposuction and transplantation surgery. However, some issues still need to be noted in clinical work: minors under 18 years old should preferably be accompanied by their parents; elderly people mostly have diminished functions of heart, lungs, liver and other organs, and are less tolerant of surgery, especially elderly patients over 70 years old, who have a higher probability of serious complications and need to be carefully selected. Although the function of all major organs is not severely diminished, preoperative evaluation should be adequate, with good preoperative history questioning and close intraoperative and postoperative observation. For young people, fat suction or transplantation surgery is certainly safer, still should not be careless, to regular medical institutions, under the guidance of qualified professionals to choose the appropriate method. Don’t be greedy, too much trouble and ask for a “one-time operation”, but should follow the “step-by-step, principle” scientific implementation of the operation. For fat transplantation patients, it is important to know that fat will be absorbed to a certain extent, and it is necessary to perform the surgery in small amounts and several times.