Mycobacterial ear infection, also known as mycobacterial otitis externa commonly seen in ENT clinics, is mostly caused by mycobacterial cross-infection due to blind ear digging and ear picking, and mostly has clinical symptoms of odd itchy ear canal, ear leakage and ear stuffiness. Treatment is usually divided into two steps: i. Ear canal cleaning. All secretions in the external ear canal must be thoroughly cleaned first, otherwise the next step of treatment will be affected. Some of them need to be fully softened with sodium bicarbonate injection before cleaning, or even repeated several times before they can be cleaned. Before the first cleanup, leave the secretions to send culture and drug sensitivity test. Second, local anti-mycotic treatment. Usually no systemic oral medication is needed, you can use hydrogen peroxide irrigation followed by fluconazole eye drops ear bath 3 times a day. You can also use tretinoin acetate econazole cream applied all over the external ear canal once a week. Also, be sure to quit the bad habit of digging your ears.