Calf muscle pain in diabetic patients is usually considered to be due to lower limb arterial occlusion, increased lactic acid due to exercise or muscle damage caused by statin drugs. 1. The formation of thrombus in the deep veins of diabetic patients will cause obstruction of venous return in the lower limbs, resulting in muscle stiffness, pain and other symptoms in the calves, at this time it is generally necessary to anticoagulant therapy through low molecular heparin and other anticoagulant therapy. 2. If diabetic patients have had strenuous exercise before, then it will cause an increase in lactic acid production, stimulating muscle swelling, pain, at this time generally can be relieved through rest. 3. When diabetic patients take oral statins and other drugs for treatment, it is easy to trigger rhabdomyolysis, muscle pain, swelling, at this time, the need to stop statins and give the protection of the cell membrane of the drug treatment. In addition, it can not be ruled out that the patient may have calf neuropathy, in short, diabetic patients with muscle pain for more reasons, it is recommended to consult a doctor in time to clarify the diagnosis.