For patients with herpes zoster neuralgia combined with diabetes mellitus, it is necessary to take general measures for herpes zoster and diabetes mellitus as well as medication. 1. General measures: patients with herpes zoster should keep the affected area clean and dry, avoid scratching, and wear loose clothing to prevent friction on the affected area. For diabetic patients need balanced nutrition, control the daily intake of total calories, eat small meals, and appropriate physical exercise. In addition, patients need to monitor their blood sugar regularly and learn more about diabetes. 2. Medication: For neuralgia caused by herpes zoster, antiviral drugs such as acyclovir and valacyclovir should be used under the guidance of a doctor. Some patients with severe nerve pain need to use calcium channel modulators such as pregabalin and gabapentin, or non-steroidal anti-inflammatory drugs such as acetaminophen and ibuprofen as directed by a doctor. For diabetes, sulfonylurea hypoglycemic drugs such as glibenclamide and glipizide should be used under medical supervision. Apart from this, patients can also be treated by insulin injections as prescribed by the doctor. It is recommended that patients with herpes zoster neuralgia combined with diabetes need to seek timely medical treatment, and the doctor will choose appropriate measures to treat the patient’s condition.