The genetic factors: some patients have family aggregation phenomenon, may belong to polygenic inheritance; 3, neurochemicals: biological chemicals released from the skin nerve endings, have a destructive effect on melanocytes, can lead to reduced melanin production; 4, trace elements: the body’s trace elements reduced, such as copper levels, may lead to vitiligo; 5, mental factors: most vitiligo patients in the development or The development stage of skin lesions, there will be mental trauma, emotional tension, depression, etc.; 6, other factors: such as trauma, sun exposure and other reasons, may lead to the development of vitiligo. Therefore, it is believed that vitiligo is a multi-factor autoimmune disease, but the exact cause is not clear. If vitiligo appears, it is recommended to actively choose a regular hospital for systematic treatment.