Which is recommended to reduce blood uric acid, febuxostat or benzbromarone, needs to be decided according to the condition, although febuxostat and benzbromarone belong to the drugs to reduce the concentration of uric acid in the blood, but the mechanism of action, indications and side effects of the two are different, so they should be based on their own condition, choose the right drug for themselves. 1. Mechanism of action: Febuxostat reduces serum uric acid concentration by inhibiting uric acid synthesis. Benzbromarone reduces blood uric acid concentration by inhibiting the reabsorption of uric acid in renal tubules. 2. Indications: Febuxostat is suitable for the long-term treatment of hyperuricemia in gout patients, but cannot be used to treat hyperuricemia without clinical symptoms. Benzbromarone is mostly used in the treatment of primary hyperuricemia, gouty arthritis intermittent period. 3. Side effects: Febuxostat has relatively more side effects, such as increased heart rate, headache, chest pain and cerebrovascular disease. Benzbromarone has fewer adverse reactions, the most common are gastrointestinal reactions, such as nausea, vomiting, loss of appetite, etc., which are generally tolerated. The choice of drug needs to be based on the condition, if there is no symptomatic hyperuricemia, febuxostat is not recommended. It is contraindicated for those who are allergic to the drug. Pay attention to the monitoring of liver and kidney function during the use of the drug, drink plenty of water. If the patient needs to use the drug, it is recommended to go to the hospital in time after the doctor’s diagnosis and treatment, and follow the doctor’s instructions to use the drug, avoid blindly use the drug or change the dosage.