Second-line chemotherapy drugs for ovarian cancer mainly include paclitaxel, doxorubicin, cisplatin and so on. After adopting first-line chemotherapy program, the patient is effective, but after a period of time, the disease recurs and progresses due to the decrease in sensitivity of chemotherapeutic drugs, and then the chemotherapy is the second-line chemotherapy. There are many second-line chemotherapeutic drugs for ovarian cancer, and the more common ones are paclitaxel, doxorubicin, cisplatin, cyclophosphamide, etc. Specific drugs need to be combined with the patient’s pathological type, clinical staging, physical condition and other factors to be determined. Chemotherapy is one of the more important means for ovarian cancer, which can be treated by single drug and single chemotherapy program, or combined with surgery, radiotherapy, targeted drugs or multiple chemotherapy drugs for comprehensive treatment, and most patients can effectively relieve their conditions and symptoms after treatment.