The palms of the hands appear significantly red and itchy state, you need to determine what is the case according to the appearance of the skin . 1, if the surrounding skin is basically flat with normal skin when red and itchy, then consider the possibility that it is, simply erythema of the palms of the hands. This situation is related to allergy and is an immune response of the skin stratum corneum after contact with certain allergic and irritating substances, and it is recommended to choose to use glyburide lotion for treatment. 2. If obvious red blisters can be seen on the red, itchy skin, and white pus can be seen in the middle of the blisters, then consider the possibility of palmoplantar pustulosis, which is a special type of psoriasis. The actual fact is that it is a special type of psoriasis, which is a change formed after the specific factor acts on the skin surface. 3, if the itchy palms are not intense, and the red spots are scattered and spread gradually to the arms and forehead, then consider that it may be syphilis second stage rose rash, which is a change formed after the syphilis spirochete acts on the skin surface.