Patients with liver disease may have redness between the large and small fissures of the palms of the hands that fades when pressed, clinically known as hepatic palms, but redness in the palms of the hands can also be caused by other physiological or pathological factors such as skin diseases of the hands, external tapping or friction. Therefore, if redness persists in the palms of the hands, it is important to seek medical attention and have the relevant tests performed to clarify the diagnosis.