Colorectal cancer includes colon cancer and rectal cancer. Its liver metastasis is very common. In the past, it was considered that colorectal cancer with liver metastasis was already in advanced stage. If there is no intestinal obstruction, surgery is not recommended, but only chemotherapy. Recent studies have shown that liver metastasis from colorectal cancer is not the only way to wait for death. Through neoadjuvant chemotherapy, about 15% of patients with reduced or shrinking liver lesions can be surgically resected or radiofrequency ablated, while radical colorectal cancer surgery is performed, and these patients can achieve long-term survival. There are 2 types of liver metastases: 1. Isolated metastases: if they can be resected, partial hepatic resection or radiofrequency ablation can be performed at the same time as colorectal cancer surgery. If the metastases are huge and cannot be resected, surgical resection can be considered after neoadjuvant chemotherapy and lesion reduction. 2.Multiple liver metastases: it is more common. Sometimes at first glance the liver is full of nodules of different sizes, and it seems that nothing can be done. In fact, after neoadjuvant chemotherapy part of the patients may only have a small number of residual lesions, and these lesions can precisely be solved by surgery or radiofrequency ablation. Long-term survival is still possible in this group of patients. Although this part of patients only accounts for 15% of liver metastases from colorectal cancer, how lucky for a single patient if he is within this 15%!