The difference between mother-to-child infection and acquired infection of hepatitis B is mainly the route of infection, the outcome of infection, the impact on treatment, as follows: 1. low population, the general virus is difficult to clear, so most of them become hepatitis B virus carriers, after a certain age can develop, the development of chronic hepatitis B, and even progress to cirrhosis and liver cancer, acquired infection is generally infected with adults or at least children older than 5 years old, due to enhanced immunity, resulting in more acute infections, acute infection is generally about 95% can be cured, so acquired infection Hepatitis B generally has a better prognosis; 3, the impact on treatment: interferon and other antiviral treatment of mother-to-child transmission is often poor, acquired infection is more sensitive to interferon because of the relatively short years of infection and strong immunity, so the interferon treatment effect is sensitive.