A male 63 years old with stage II membranous nephropathy- nephrotic syndrome Complaint: edema for more than 2 months. History: In May 2014, the patient developed bilateral lower extremity edema after exertion, and urine examination showed PRO (3+) and RBC 120/ul; 2 months later, he was seen at Beihang University Hospital for worsening edema, and urine examination showed RBC 150/ul; UTP 3.5g/d; biochemistry: ALB 34.1g/L, Scr 80umol/L, Tch 6.8mmol/L. Pathological return after renal puncture showed stage II membranous nephropathy. After 1 week of treatment with valsartan 40mg Qd, atorvastatin calcium tablets 20mg Qn and diuretics, the patient was discharged with reduced edema. After taking the drug for 1 week, the blood pressure was maintained at about 85/60 mmHg, so it was discontinued. In order to seek TCM treatment, the patient was admitted to our department in July 2014. Past history: history of eczema of the left lower extremity for more than 3 years, and had sought treatment for Chinese and Western medicine for several times without success; denied history of other chronic and infectious diseases. Pathology report: immunofluorescence: 4 glomeruli, IgG (++++), IgA (-), IgM (-), C3 (++++), FRA (+), C1q (-), IgG1 (-), IgG2 ( -), IgG3 (-), IgG4 (++++), HBcAg (+), PLA2R1 (+++), with granular deposits along the capillary wall. Light microscopy: 28 glomeruli were seen, 1 with ischemic sclerosis and the rest with extensive vacuolar degeneration of the glomerular capillary basement membrane, mild segmental thickening, slight proliferation of thylakoid cells and stroma, and subepithelial eosinophilic deposits, 2 of which were ischemic crinkled. Renal tubular epithelial vacuolation and granular degeneration with small focal (about 5%) atrophy. Small focal lymphoid and mononuclear cell infiltrates with fibrosis in the renal interstitium. Small arteriolar wall thickening. Electron microscopy: thickening of the glomerular basement membrane, deposition of most electron-dense material under the epithelium, and diffuse fusion of epithelial cell peduncles. There were no specific lesions in the renal tubules and interstitium. At the time of consultation: TP 5.5g/d; biochemistry: ALB 29.4g/L, swelling of the lower limbs, rash breaking and oozing from the right lower limb, red tongue with yellowish coating. Western medicine diagnosis: 1, stage II membranous nephropathy, nephrotic syndrome 2, left lower extremity skin eczema Chinese medicine diagnosis: edema, spleen deficiency and wind-dampness Treatment: strengthen the spleen, benefit the qi, dispel wind and remove dampness Formula: Ma Heng Coixi Gan Tang combined with Fang Ji Huang Qi Tang plus reduction and with the wind dispelling and anti-itching Chinese medicine external washing Follow-up treatment: the above plus reduction treatment to March 2015 the patient urine protein significantly reduced, 24-hour urine protein quantification of 1.1 g. November 2015 In November 2015, the urine protein turned negative, plasma albumin returned to normal, and the rash of the lower limbs for many years also basically disappeared.