The difference between infantile emergency rash and hand, foot and mouth disease are different causes, different clinical manifestations and so on. 1. The cause of the disease is different: infantile rash is caused by human herpes virus type 6, type 7 and other viral infections. Hand, foot and mouth disease is caused by coxsackievirus A16, enterovirus 71 and other viral infections. 2. Clinical manifestations are different: infantile rash to fever, rash as the main manifestations, generally repeated high fever 3 ~ 5 days after the body temperature returns to normal, the heat out of the rash, the rash for the reddish blotchy papules, can be all over the body, mostly in 1 ~ 2 days after the subsidence. Hand, foot and mouth disease is mainly manifested in the hands, feet, mouth, buttocks and other parts of the rash, herpes, ulcers, may or may not be accompanied by fever, severe cases can be complicated by encephalitis, meningitis and so on. In addition, the two are different in terms of treatment and disease precautions. Young children suspected of infantile emergency rash, hand, foot and mouth disease, etc. may need to consult the doctor in a timely manner, after a clear diagnosis, follow the doctor’s instructions to carry out targeted treatment, so as to avoid delaying the treatment time.