How to confirm the diagnosis of chronic renal failure is generally based on three aspects: 1, according to the patient’s clinical symptoms: according to the patient’s clinical performance, clinical performance for chronic renal failure, can involve all organs of the body, multi-system will be affected. Many patients with renal failure, the first manifestation is in the digestive tract, with the rise of creatinine, the patient will appear nausea, reduced appetite, vomiting and other such symptoms, many patients to the gastroenterology department found creatinine elevated; for cardiovascular is also a different performance, such as patients will appear panic, and blood system abnormalities, renal failure patients are often accompanied by renal anemia. When renal anemia is present, patients will experience weakness, fatigue, and lack of energy. For the renal system, proteinuria and hematuria may be found during the physical examination, which are also common clinical symptoms; 2. According to the laboratory results: first of all, the laboratory tests, this value is a definite value, below this value can be considered that the patient is not to renal failure. More than this value, the patient can be given a diagnosis that has kidney failure. According to the criteria, a creatinine of more than 133 µmol/L is considered for the diagnosis of renal failure. There is another criterion is creatinine clearance, creatinine clearance below 80 ml/min, has reached the stage of renal failure; 3. Judgment according to imaging examination: through imaging examination, most chronic kidney patients, will have kidney changes, the most common is kidney shrinkage; there are also some patients will not appear kidney shrinkage, such as diabetic nephropathy, the beginning of the kidney even slightly larger. Therefore, a clear diagnosis should be made by combining the patient’s clinical manifestations, laboratory tests and imaging.