Loratadine belongs to the second generation of highly effective and long-lasting tricyclic antihistamines with fewer central nervous system side effects such as drowsiness compared to the first generation antihistamines. At the recommended dose of 10 mg per day, no significant sedative effect has been observed. Common adverse reactions to loratadine include malaise, headache, drowsiness, dry mouth, gastrointestinal upset including nausea, gastritis, and skin rash. Rare adverse reactions include alopecia, allergic reactions, abnormal liver function, tachycardia, and palpitations. The use of this product should be discontinued approximately 48 hours prior to skin testing because antihistamines can prevent or reduce the occurrence of positive skin test reactions. The dosage should be reduced for hepatic and renal insufficiency. 10 mg every 2 days or under medical supervision is recommended. Drowsiness, cardiac arrhythmias, and headache may occur with overdose of this product (40-180 mg) in adults. Give immediate symptomatic and supportive therapy as soon as these symptoms occur. The safety and efficacy of this product have not been established in children under 6 years of age. Patients with severe hepatic insufficiency and those who are using other drugs should consult a physician or pharmacist before using this product.