The patient, male, 36 years old, was admitted to the hospital at the end of 2011 with progressive swelling and pain in the right ankle and limitation of activity for one month. After spraining his ankle in January before admission, he had pain and swelling in his right ankle, with limited walking activities. He was first admitted to a hospital in Shenzhen, and then transferred to the Bone and Joint Department of Shenzhen No.2 Hospital after being suspected of “malignant osteosarcoma” by photo examination. After detailed examination, it was found that the scope of osteolysis of the patient had rapidly expanded from the lower end of tibia to the lower part of tibiofibula and tarsal bones such as talus and Achilles, and it was still expanding rapidly, and the consequences would be unimaginable if the patient could not take effective treatment measures to stop the progression of the lesion. Orthopaedic specialist Dr. Zhang Shiquan decided to perform a puncture biopsy after consultation. During the operation, it was found that the lesion was extremely rich in blood flow, and there was jet-like bleeding in the puncture hole, which required dense suture and pressure bandage to stop bleeding. The biopsy tissue was read by Dr. Guan Hong, director of the Department of Pathology, and was initially diagnosed as massive osteolysis. Because it is a rare and difficult case, Mr. Guan sent the biopsies to hospitals in Shanghai and Guangzhou to seek more expert opinions. However, some experts believe that the malignant tumor, suggesting that the patient amputation surgery. The orthopedics and pathology experts of the Second Municipal Hospital maintained the diagnosis of “massive osteolysis” after discussing and reviewing a large number of domestic and international literature, combined with the patient’s clinical, imaging and pathology data. After fully communicating with the patient and his family, it was decided to adopt limb preservation treatment. After comprehensive treatment with bisphosphonates and other medications, the patient’s symptoms were significantly relieved, and imaging showed a significant reduction in the scope of the lesion, with osteogenesis occurring in some of the osteolyzed areas. Experts expect that with further treatment, the patient will be able to avoid amputation and save his limb. Massive osteolysis, or Gorham Stout syndrome, is known as “ghost bone” in Chinese medicine and “phantom bone” in the West. It is a rare disease characterized by a large number of capillaries and fibrous tissue proliferation at the lesion site, accompanied by progressive osteolysis, with fewer than 200 cases reported at home and abroad. Its etiology and pathogenesis are not clear, and it is generally believed that it may be related to trauma, infection, ischemic necrosis, hemangioma or lymphangioma, etc. Due to the rarity of the disease in the clinic, it is easy to be misdiagnosed as malignant tumor, osteomyelitis, osteonecrosis, etc. In 2005, the UK reported its first case of osteolysis, and when taking an X-ray film, the 4 year old Alex was found to have a completely “disappeared” jawbone! disappeared”! After a new jawbone was transplanted, the replacement bone also gradually “dissolved.” …… British doctors were at their wits’ end. The treatment of osteolysis has no ideal method, foreign doctors have tried to use radiation to promote the remineralization of dissolved bone, but can not stop the development of the disease.