The solution to severe constipation in diabetes mellitus, first of all, we should control the blood sugar, and secondly, we can treat it by oral laxative drugs such as lactulose, topical drugs such as keserol, as well as improve the habits of life and diet, etc. It is recommended to keep the bowel movement smooth in normal times, and to supplement foods with high dietary fiber in moderation on the basis of stable blood glucose control. Severe constipation in diabetes mellitus may be due to the emergence of autonomic neuropathy as a result of long-term poor glycemic control, causing gastrointestinal system symptoms manifesting as diarrhea or constipation, or it may be related to poor dietary and living habits. It is recommended that such patients should control their blood glucose through diet, medication and exercise. In addition, you can also take oral laxative drugs: you can take 20% mannitol, lactulose oral solution and other laxative drugs, to play the role of laxative. Use of external drugs: can be used externally to relieve constipation, or can be enema, the above methods can also relieve constipation. Improve the living habits and dietary habits: usually keep the bowel movement, avoid sitting for a long time, and do not squat for too long in the toilet. If the blood sugar control is stable, you can eat some food rich in crude fiber and vegetables and fruits. When diabetic patients have serious constipation, it is recommended to go to the hospital in time, and choose the appropriate way under the guidance of the doctor to carry out the treatment.