There has been an increase in the number of humeral stem fractures with bone nonunion in recent years, many of which are due to improper treatment. The main medical factors that cause osteochondral nonunion are: long steel plate stripping the periosteum too much, or too short steel plate leading to screw release, plate breakage; screws into the fracture line. Re-plate fixation should not be the preferred method in cases of first plate fixation failure. Intramedullary nail, bone round pin fixation of the fracture end is unstable, insufficient resistance to rotation, nail displacement withdrawal loss of fixation. Inappropriate external fixation frame fixation, presence of stress masking. Severe soft tissue trauma in the fracture area, infection, ischemia Treatment: Intramedullary nailing with locking or shaped plates is an effective fixation method for the treatment of humeral osteochondral nonunion. Due to the sclerosis of the humeral bone discontinuity and the osteochondral laxity of the bone stem, there are plates, wires and nail holes left from previous surgeries, or the thinning of the cortex due to bone resorption, it is difficult to obtain reliable results with internal fixation of the plate. The locking intramedullary nail provides more uniform elastic stress distribution between bone tissue and nail body, avoids extensive soft tissue stripping during internal fixation of the plate, has a stronger anti-rotation effect than the flexible intramedullary nail, does not require external fixation, has good stability of the broken end, can better solve the fixation problem in cases of osteoporosis, thinning of the bone stem and bone defects, and can be used for early functional exercise, so it is better than the plate, external fixator and flexible intramedullary nail in the treatment of long diaphyseal bone. It has better features than plate, external fixation frame and flexible marrow nail in the treatment of long diaphyseal discontinuity. Bone grafting with bone marrow cells can promote fracture healing: Bone discontinuity with bone defect, bone resorption and deformity at the fracture end is called “refractory bone discontinuity” after repeated surgical failure, and it is more difficult to treat it by surgery again and it is still prone to failure. Bone marrow stromal cells can differentiate into osteoblasts and stimulate other cells in the recipient area to transform into osteoblasts and chondrocytes in the specific environment of implantation in the body, and have the ability to synthesize bone matrix and promote bone repair.