There is an increasing trend of nonunion in humeral stem fractures in recent years, many of which are caused by improper treatment. The main medical factors causing nonunion are: long plates stripping the periosteum too much, or plates that are too short, resulting in screw loosening, plate breakage, and screws driven into the fracture line. Re-plating should not be the preferred method in cases where initial plate fixation has failed. Intramedullary nails, bone round pins fixation of the broken end is unstable, insufficient anti-rotation, nail displacement withdrawal loss of fixation. Inappropriate external fixation bracket fixation with stress masking. Severe soft tissue trauma, infection, ischemia in the fracture area. Treatment: Locking intramedullary nails or allograft plates are effective fixation methods for the treatment of humeral nonunion. Reliable fixation with a plate is difficult to achieve due to the sclerotic nature of the humeral osteochondral disruption and the osteoporotic nature of the diaphysis, the presence of plates, wires, and nail holes from previous surgeries, or due to bone resorption with thinning of the diaphysis and thinning of the cortex. Locking intramedullary nails provide a more uniform distribution of elastic stress between the bone tissue and the nail body, avoiding extensive soft tissue stripping during internal fixation with steel plates, stronger anti-rotation effect than flexion intramedullary nails, no need for external fixation, good stability of the broken end, a better solution to the fixation of osteoporosis, thinning of the backbone, and bone defects, etc., and can be used for functional exercise in early stage, so it has a better effect on the treatment of long backbone bone disunion than steel plates, external fixation frames and flexible intramedullary nails. Therefore, it is superior to steel plate, external fixation frame and flexable marrow nail in the treatment of long diaphyseal osteochondrosis. Sufficient bone grafting Bone grafting with composite bone marrow cells can promote fracture healing: Bone nonunion with bone loss, bone resorption and deformity at the fracture end after repeated failed surgeries is known as “resistant nonunion”, which is more difficult to be treated by surgery again and is still prone to failure. Bone marrow stromal cells implanted in the body in a specific environment can be differentiated into osteoblasts, and can stimulate other cells in the affected area to be transformed into osteoblasts and chondrocytes, and have the ability to synthesize bone matrix, which has the effect of promoting bone repair.