Since the first antifungal drug Amphotericin B was introduced, the struggle between human and fungus has lasted for more than 40 years. In recent years, with the widespread use of broad-spectrum antibacterial drugs, immunosuppressants, organ transplantation, hemodialysis and radiotherapy, the incidence of fungal infections has increased year by year and has become a public problem that seriously affects people’s health, so a reasonable choice of antifungal drugs has a very important role in the treatment of fungal infections. Clinically used antifungal drugs mainly include the following: 1, polyenes: representative drugs for amphotericin B, mycoplasma. Systemic systemic administration, mainly for the treatment of deep fungal infections, but due to high nephrotoxicity limits its clinical application, currently mainly used for the treatment of oral, vaginal and skin Candida albicans infections. 2, azoles: representative drugs are ketoconazole, fluconazole, itraconazole, voriconazole, etc., is currently the most widely used clinical antifungal drugs, mainly for a variety of Candida, cryptococcosis and a variety of fungal meningitis and immunocompromised patients with oral and gastrointestinal candidiasis, the efficacy is better, more than a certain degree of hepatic and renal toxicity, but toxicity is smaller than polyolefins. 3, allylamines: representative drugs are butenafine and terbinafine, clinical more for shallow fungal infections. 4, echinocandins: most Candida have rapid fungicidal effect, including some strains of azole resistance, for most Aspergillus also have inhibitory effect, clinically show broad-spectrum, low toxicity, high efficiency characteristics, the representative drug is known as the antifungal “penicillin” of the name of the carpofungin, the drug efficacy is precise, less adverse reactions, although expensive. Despite the high price, the dosage has increased significantly. For some patients with serious underlying diseases, prolonged illness or immunosuppressants, carbapenem antibiotics should be more alert to the occurrence of fungal disease, should be timely to identify the pathogenic fungi, do a good job of fungal isolation culture identification and drug sensitivity test, from the pathogenic fungal species and drug characteristics and the patient’s systemic condition and economic status and other aspects of comprehensive consideration, the correct and reasonable choice of antifungal drugs or combination To explore and develop a highly effective, low toxicity and economic treatment plan.