Big toe pain in diabetic patients may be caused by diabetic peripheral neuropathy, and if it is accompanied by rupture, it may have progressed to diabetic foot. 1. Diabetic peripheral neuropathy: It is a common complication in diabetic patients and is common in people with poor blood sugar control. Symmetrical pain or numbness in the extremity endings, ants crawling sensation, etc. may occur. Pain in the big toe may occur. At this time, strict control of blood sugar is needed to avoid foot injury. 2. Diabetic foot: diabetic patients in the above peripheral neuropathy, and peripheral blood vessels on the basis of lesions, if the foot breaks down, can develop into diabetic foot. Pain in the big toe may occur, accompanied by localized ulceration, oozing or blackening and other manifestations. Diabetic foot is a more serious lesion that can easily become disabling, and prevention and early treatment are critical. Diabetic patients should seek medical attention as soon as they experience pain in the big toe without delay to prevent the condition from progressing to a stage where amputation is required.