Eyelid puckering is mainly manifested as a sebaceous flaky local metabolite shedding that occurs on the eyelid skin. It is mainly related to the individual’s body type, the metabolic status of the endocrine system and the nature of the individual’s skin. It can also be caused by diseases of the eye itself or secondary to other systemic diseases. People with less oily skin are prone to eyelid peeling, which is mainly caused by dry skin. People who smoke and drink a lot and stay up late are also prone to eyelid puckering, which is related to endocrine disorders. Eye diseases that cause eyelid flakiness include inflammation of the lid margin, including canthal blepharitis, ulcerative blepharitis, and scaly blepharitis, in which patients develop a flaky substance on the surface of the eyelid skin. Of course, it has also been suggested that eyelid flakiness is related to a systemic vitamin deficiency, often occurring in people who are picky eaters, have an unbalanced diet, and usually consume more meat and fewer vegetables. The eyelid skin is also related to seasonal factors, some people in the spring and summer season eyelid skin easily, but rarely occur in autumn and winter, mainly because the eyelid local sensitivity to the dry environment and caused. In summary, the causes of eyelid flakiness are mainly related to individual conditions and the external environment.