As the saying goes, “the autumn breeze is rising, the autumn fat is on”, and in this age of over-nutrition, fatty liver is increasingly detected in medical examinations. However, most people only consider it as a sub-healthy state and do not pay enough attention to it. In fact, fatty liver disease has become the second largest liver disease after viral hepatitis in China, and is the primary cause of abnormal liver function (increased serum aminotransferases) in adult health checkups, and is a common cause of cryptogenic cirrhosis. In the face of health threats, how should we achieve comprehensive, scientific and effective prevention and treatment? Professor Fan Jiangao, head of the Fatty Liver and Alcoholic Liver Disease Group of the Chinese Medical Association’s Hepatology Branch, says that there are three key words to master in “scientific liver care”: The first key word is to know yourself and your enemy. First, we must recognize the danger of fatty liver. It is found that liver with fat accumulation is more fragile than normal liver, and it is more vulnerable to viral infection, drugs, industrial toxins, etc., resulting in a higher incidence of liver injury. When multiple causes of liver damage are combined, the degree of hepatitis is increased and the progression of liver fibrosis is accelerated, resulting in a significant increase in mortality associated with liver disease. In addition, patients with fatty liver have an increased risk of developing diabetes, hypertensive disease, and even heart disease in the near future. Therefore, once fatty liver is diagnosed, it should not be taken lightly. For fatty liver detected by ultrasound during physical examination, the severity of the disease can be further analyzed in combination with blood tests. If the serum aminotransferase continues to increase for more than half a year, it often indicates the presence of steatohepatitis, and if there are also abnormal liver fibrosis indicators, it indicates the complication of liver fibrosis, so we should pay great attention to it. The second major keyword is prevention. In the early fatty liver stage before the occurrence of liver fibrosis, the lesions are reversible. Following early intervention, including diet adjustment, correction of nutritional imbalance, and adherence to exercise to maintain ideal body weight, can help to nourish the liver. Some patients often experience fatigue and weakness and discomfort in the liver area. When they are examined and heard that the transaminases are elevated, they think it is due to excessive fatigue. In fact, for patients with steatohepatitis associated with obesity, what is needed is increased exercise and diet moderation. For patients with fatty liver or alcoholic hepatitis who have a long history of excessive alcohol consumption, complete abstinence from alcohol is necessary. The third keyword, standardized treatment The treatment of steatohepatitis cannot be based on diet and exercise alone, as this approach is not suitable for all patients with steatohepatitis. For patients with chronic wasting disease, fatty liver due to protein-calorie deficiency, and alcoholic liver disease combined with malnutrition, it is usually necessary to increase dietary calorie and vitamin and protein intake. In patients with fatty liver due to hepatotoxic drugs, excessive exercise interferes with liver metabolism and is detrimental to disease recovery. In addition, once simple fatty liver progresses to the stage of steatohepatitis with liver fibrosis, simple lifestyle changes rarely lead to remission of intrahepatic inflammation and fibrosis, which usually requires concomitant use of liver-protective drugs such as adenosylmethionine. Clinical studies have shown that adenosylmethionine has the ability to increase hepatocyte detoxification and bile excretion, thereby promoting recovery. Therefore, patients with steatohepatitis and cirrhosis should use hepatoprotective drugs such as adenosylmethionine reasonably under the guidance of doctors for a good prognosis. Finally, Professor Fan Jiangao emphasized that cultivating a healthy lifestyle is the best way to nourish and protect the liver.