There is no clinical antibiotic of choice for skin soft tissue infections, skin soft tissue infections usually refer to skin and subcutaneous tissue infections, generally caused by Streptococcus haemolyticus and Staphylococcus aureus, can use β-lactams, aminoglycosides, tetracyclines, macrolides antibiotics, the specific use of drug sensitivity test to decide. 1, β-lactams: can be used to treat gram-positive The antibiotics include penicillins, cephalosporins, carbapenems and so on. Commonly used penicillins include procaine penicillin, ampicillin, amoxicillin, etc.; commonly used cephalosporins include cefuroxime, cefotaxime sodium, ceftazidime, ceftriaxone sodium, etc.; carbapenems include imipenem, meropenem, etc.; 2, aminoglycosides: applicable to infections caused by gram-negative bacilli, drugs include streptomycin, neomycin sulfate, kanamycin sulfate, gentamicin sulfate, etc.; 3 3, tetracyclines: mainly used for chlamydia, mycoplasma infection, including tetracycline, chlortetracycline, oxytetracycline and semi-synthetic tetracycline doxycycline, metacycline hydrochloride and minocycline hydrochloride, etc.; 4, macrolides: for gram-positive bacteria have strong antibacterial ability, including erythromycin, roxithromycin, cross-samplex, clarithromycin, azithromycin, methicillin, acetylspiramycin, guillamycin, etc.; 5 In addition to good antibacterial effect on Gram-negative bacilli, quinolones further enhance the killing effect on Gram-positive cocci, Mycobacterium tuberculosis, Legionella, Mycoplasma and Chlamydia, especially improve the antibacterial activity on anaerobic bacteria such as Bacteroides fragilis, Clostridium perfringens, Streptococcus digestiveis and Clostridium anaerobicus. Common drugs include ciprofloxacin, ofloxacin, norfloxacin, lomefloxacin hydrochloride, levofloxacin, moxifloxacin, gemifloxacin, gatifloxacin, etc.