Cyber knife, also known as “stereo-localized radio wave surgical platform”, “cyber knife” or “computer knife”, is the world’s newest full-body, stereo-localized It can treat tumors in all parts of the body. It can treat tumors in all parts of the body and can kill tumor tissues with only one to five irradiations. It is the only form of total body radiosurgery that combines the advantages of “no wounds, no pain, no bleeding, no anesthesia, and a short recovery period”, and the patients can go home after the operation. At present, more than 200 medical units around the world use this new cancer treatment equipment, radio wave knife was published in Forbes as a pioneer of high-tech medical products, and was named by the World Economic Forum as one of the world’s most important medical products. and has been recognized by the World Economic Forum as a “Global Technology Pioneer” program. It is the only device that uses real-time image-guidance technology, the only system that utilizes the body’s skeletal structure for target orientation and beam correction, and the only radiosurgical tool that tracks the patient’s breathing in real time during “surgery” to dynamically irradiate the body’s lesions. The image guidance technology includes two sets of diagonal (X-ray 90-degree cross) X-ray image developers, which detects the displacement of the target area on the X-ray image in real time during the “surgery” process and performs dynamic irradiation of thoracic and abdominal tumors that are in motion with breathing, making real-time compensatory corrections to ensure the accuracy of the “surgery”. This ensures the accuracy of the “surgery”, so that the radiation is completely irradiated on the tumor, which will not hurt other surrounding tissues and institutions, and plays the role of protecting normal tissues, so that the patients have no abnormal reaction after the treatment, and the side effects are smaller. In 2001, CyberKnife was approved by the U.S. Food and Drug Administration (FDA) to treat patients with tumors for which radiation is applicable anywhere in the body. Since then, CyberKnife users have begun to develop and continue to formulate treatment blueprints for treating tumors of the brain, spine, lungs, liver, pancreas, kidneys and prostate. We describe these applications and the methods by which they have been realized by CyberKnife users in detail on these pages. As these clinical developments progress smoothly, the technology is evolving under clinical guidance. As a result, patients can be treated with the best and least invasive radiosurgical procedures.