The development of cancer and its recurrence and deterioration are closely related to psychosomatic factors, and this is a unanimous understanding in ancient and modern times, with some scholars explicitly referring to cancer as a “psychosomatic-related disease”. As early as in the Song Dynasty, Zhu Danxi, when discussing the mechanism of breast cancer, concluded that over the years, interpersonal relationships were tense, and women were “not allowed to be in the company of their aunts and sisters-in-law” and “not allowed to be in the company of their in-laws”, and depression was one of the main causes. Depression is one of the main causes. Unexplained sadness is closely related to breast cancer; emotional stress can enhance the patient’s susceptibility to cancer and change the course of the disease; the effectiveness of cancer treatment varies according to the patient’s mood and personality; patients who are convinced that they have cancer will often deteriorate rapidly and die despite early treatment; those who are skeptical of cancer often have a better outcome. Recurrence is also related to psychological factors. Many people experience severe emotional stress in the 6-18 months prior to recurrence; cancer patients with strong paranoid symptoms experience slow growth of the mass; and many cancer patients who recover spontaneously are schizophrenic. How can psychosomatic factors cause cancer? There are various related hypotheses, and the following ones are more worthy of attention. 1. Negative emotional accumulation theory: it can be said to be one of the high-risk factors promoting cancer. There are two types. The first type is severe frustration in childhood, especially the loss of affection with extreme hopelessness, such as the death or departure of one of the parents in the early stage, with the accumulation of negative emotions of punishment and loneliness, the feeling of social rejection and emotional instability, and later on, with the accumulation of life, the child maintains and deepens this sense of disconnection. The second type is the hopeless emotion of the elderly, the accumulation of negative emotions in the adult years and years, and eventually the signs of cancer. 2. Bereavement: Many studies have found that the death of a loved one is an important factor leading to cancer. In fact, bereavement itself is only a psychological stressor, and the intensity and nature of the grief process is the key to the adverse emotional reaction, i.e. the individual’s psychological reaction to the bereavement event. 3, depression: in the adverse emotional reactions, the closest relationship with cancer is depression, intense frustration, hopelessness and helplessness. Some people think that “depression catalyzes the tumor”. 4, personality: “C-type personality” is considered to be more than three times higher than the general incidence of cancer, the personality characteristics of its overly patient, conflict avoidance, excessive cooperation, yielding concessions, control of negative emotions, the pursuit of perfection, and efforts to suppress self, not good at revealing emotions and so on. How can psychosomatic factors cause cancer? It is generally believed that it mainly acts on the central nervous system. On the one hand, it causes dysfunction of autonomic nerve and endocrine function through the nervous system, immune function is suppressed, and the internal environment of the body is broken, which makes the cells easy to mutate and produce cancer cells; on the other hand, it reduces the production of antibodies in the body, which prevents lymphocytes from recognizing and destroying the cancer cells, so that the cancer cells escape the supervision of the immune system and finally form cancerous tumors. On the other hand, reducing the production of antibodies in the body prevents lymphocytes from recognizing and destroying cancer cells, so that cancer cells escape from the “supervision” of the immune system and eventually form cancerous tumor.